ABSTRACT
Introduction: With the current practice of routine Serum PSA examination, there arises a diagnostic dilemma with regard totheir further evaluation and treatment.Aim: The aim is to study the incidence of cancer (CA) prostate in cases with elevated Serum PSA.Methodology: We studied 50 men aged between 50 and 80 years with elevations in Serum PSA (total PSA) after certainexclusion criteria, these cases are given a course of antibiotics for 6 weeks and repeat Serum PSA levels obtained. In thosewith persistent elevation in Serum PSA above 4 ng/ml, transrectal ultrasound-guided biopsy was done.Results: In our study population, 36.6% of cases with persistent PSA elevation were proven positive for malignancy by biopsy.Conclusion: A fall in Serum PSA following a course of antibiotic therapy does not exclude the presence of a carcinomatouselement in prostates.